3-Bromo-1H-indole-4-carbonitrile CAS 1186663-64-8

We can provide 3-Bromo-1H-indole-4-carbonitrile CAS 1186663-64-8 with a certificate of analysis (COA), method of analysis (MOA), route of synthesis (ROS), and material safety data sheet (MSDS)

 

Chemical Properties：

Density:1.7±0.1 g/cm3

Index of Refraction:1.727

Boiling point:405.9±25.0 °C at 760 mmHg

Flash Point:199.3±23.2 °C

 

Synonyms：

3-Bromo-1H-indole-4-carbonitrile

 

Uses:

-3-Bromo-1H-indole-4-carbonitrile CAS 1186663-64-8 is used as an intermediate in organic synthesis.

Method of Preparation:

- 3-Bromo-1H-indole-4-carbonitrile CAS 1186663-64-8 can be prepared from indole.

- A cross-coupling reaction is carried out by adding 3-bromophenylboronic acid and tris(dimethylamino)stannous to the reaction solvent to obtain 3-bromopyridine.

- The 3-bromopyridine is then reacted with zinc cyanide in a nucleophilic substitution reaction to produce 3-bromo-4-cyano-1H-indole.

Safety Information:

- Specific uses and applications of 3-Bromo-1H-indole-4-carbonitrile CAS 1186663-64-8 may vary, and further research and evaluation of its detailed safety information is required at this time.

- Appropriate protective measures such as wearing protective eyewear and gloves and ensuring that the room is well ventilated are required when handling and working with this compound.

- The compound should be stored in a sealed, dry, cool place away from sources of ignition and oxidizing agents.

 

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