Introduction to pyrazine

Pyrazine is colorless crystal; It is an isomer of pyrimidine and pyridazine. Electrophilic substitution reaction is not easy to occur, but it is easy to react with nucleophiles. In nature, few of its pure products exist, but its structure is found in folic acid, which makes up the pterin part. In industry, ethanolamine is prepared by dehydrogenation under the condition of gas phase catalysis. Its derivatives have many applications, such as dibenzopyrazine is an important dye, phenazine is known for its anti-tumor, antibacterial and diuretic properties. While tetramethylpyrazine has been reported to trap superoxide anions and reduce nitrogen oxide production in the body with granulocytes.